Asenath had saved Joseph's life while she was still an infant in arms. When Joseph was accused of immoral conduct by Potiphar's wife and the other women, and his master was on the point of having him hanged, Asenath approached her foster-father, and she assured him under oath that the charge against Joseph was false. Then spake God, "As thou livest, because thou didst try to defend Joseph, thou shalt be the woman to bear the tribes that he is appointed to beget.

Asenath bore him two sons, Manasseh and Ephraim, during the seven years of plenty, for in the time of famine Joseph refrained from all indulgence in the pleasures of life. They were bred in chastity and fear of God by their father, and they were wise, and well-instructed in all knowledge and in the affairs of state, so that they became the favorites of the court, and were educated with the royal princes.