Bar Sira said: God produced drugs from the earth with which the physician heals the wound, and with which the pharmacist mixes his compounds.12The Wisdom of Ben Sira 38:4. Rabbi Simon said: There is not a single blade of grass that does not have a constellation in the firmament13A heavenly force or an angel that is in charge of it. that strikes it and says to it: ‘Grow.’ That is what is written: “Do you know the rules of the heavens?
Will you establish its dominion [mishtaro] on earth?” (Job 38:33). It is an expression of being in charge [shoter]. “Will you tie the chains of the Pleiades, or untie the reins of Orion?” (Job 38:31) – Rabbi Ḥanina bar Pappa and Rabbi Simon said: Pleiades renders fruits delicate and Orion draws it out from knot to knot.14It causes the fruits to grow to full size. That is what is written: “Will you bring out the Mazarot in its season and guide Ursa with its sons?” (Job 38:32). Rabbi Tanḥuma said: It [Mazarot] is a constellation that softens [memazer] the produce.