Rav Yitzchak said, " What is the meaning of that which is written (Ps. cxl. 8), ( Grant not, O Lord, the desires of the wicked; further not his wicked device, lest they exalt themselves. Selah? It is the prayer of Jacob to the Lord of the universe that He would not grant to Esau, "the wicked, the desires of his heart." " Further not his wicked device," this refers to Germamia of Edom (i. e., Rome), for if they (the Romans) were suffered to go forward they would destroy the whole world! Rav Chama bar Chanena said, " There are three hundred crowned heads in Germamia of Edom, and there are three hundred and sixty-five dukes in Babylon. These encounter each other daily, and one of them commits murder, and they strive to set up a king."