To the chief musician, with instrumental music. When the wicked came against [David] to seize him. This refers to what is written in (Proverbs 29:12), "If a ruler listens to lies, all his officials become wicked." When Saul's followers saw that he was inclined to listen to slanderous words about David, they immediately came to him and said, "Who is David? Who is the son of Jesse?" (Shmuel Aleph 25:10) Similarly, when Doeg the Edomite came, and when the Ziphites came to Saul and reported on David's whereabouts, they did so with the intention of causing harm to David.
Saul — Kingdom of David
Midrash Tehillim 54:1