Targum Pseudo-Jonathan on (Genesis 6:7) uses the Memra formula to absorb the Torah's most troubling phrase. The Hebrew says God "repented" that He made humanity. The Targum frames it differently.
"The Lord said, I will abolish by My Word man, whom I have created upon the face of the earth, from man to cattle, to the reptile, and to the fowl of the heavens; because I have repented in My Word that I have made them."
The regret is transferred into the Memra — the Word. God does not change. The Word speaks a verdict. This is the Targumist's classical workaround for divine anthropomorphism: God Himself is unchanging, but the Word can announce a new state of affairs without suggesting the Creator Himself has grown weary.
Notice also the scope. The punishment falls not only on humanity but on the cattle, the reptiles, and the birds. The Flood is total. When human beings corrupt the world at a deep enough level, even the innocent animals suffer. The Targumist does not try to justify this. He simply preserves it as a warning about how sweeping human sin can become.