After Hezekiah had departed this life, Manasseh ceased to serve the God of his father. He did whatever his evil imagination prompted. The altar was destroyed, and in the inner space of the Temple he set up an idol with four faces, copied from the four figures on the throne of God. It was so placed that from whatever direction one entered the Temple, a face of the idol confronted him.
As Manasseh was sacrilegious toward God, he was malevolent toward his fellows. He had fashioned an image so large that it required a thousand men to carry it. Daily a new force was employed on this task, because Manasseh had each set of porters killed off at the end of the day's work. All his acts were calculated to cast contempt upon Judaism and its tenets. It did not satisfy his evil desire to obliterate the name of God from the Holy Scriptures; he went so far as to deliver public lectures whose burden was to ridicule the Torah. Isaiah and the other prophets, Micah, Joel, and Habakkuk, left Jerusalem and repaired to a mountain in the desert, that they might be spared the sight of the abominations practiced by the king. Their abiding-place was disclosed to the king. A Samaritan, a descendant of the false prophet Zedekiah, had taken refuge in Jerusalem after the destruction of the Temple. But he did not remain there long; charges were made against him before the pious king Hezekiah, and he withdrew to Bethlehem, where he gathered hangers-on about him. This Samaritan it was who traced the prophets to their retreat, and lodged accusations against them before Manasseh. The impious king sat in judgment on Isaiah, and condemned him to death. The indictment against him was that his prophecies contained teachings in contradiction with the law of Moses. God said unto Moses: "Thou canst not see My face; for man shall not see Me and live"; while Isaiah said: "I saw the Lord sitting upon a throne, high and lifted up." Again, Isaiah compared the princes of Israel and the people with the impious inhabitants of Sodom and Gomorrah, and he prophesied the downfall of Jerusalem and the destruction of the Temple. The prophet offered no explanation. He was convinced of the uselessness of defending himself, and he preferred Manasseh should act from ignorance rather than from wickedness. However, he fled for safety. When he heard the royal bailiffs in pursuit of him, he pronounced the Name of God, and a cedar-tree swallowed him up. The king ordered the tree to be sawn in pieces. When the saw was applied to the portion of the bark under which the mouth of Isaiah lay concealed, he died. His mouth was the only vulnerable part of his body, because at the time when he was called to his prophetical mission, it had made use of the contemptuous words "a people of unclean lips," regarding Israel. Isaiah died at the age of one hundred and twenty years, by the hands of his own grandchild.