The land appointed as the inheritance of the twelve sons of Jacob was provisionally granted to Canaan, Zidon, Heth, the Jebusites, the Amorites, the Girgashites, the Hivites, the Arkites, the Sinites, the Arvadites, the Zemarites, and the Hamathites. It was the duty of these nations to take care of the land until the rightful owners should come.
No sooner had the children of Noah and their children's children taken possession of the habitations apportioned to them, than the unclean spirits began to seduce men and torment them with pain and all sorts of suffering leading to spiritual and physical death. Upon the entreaties of Noah God sent down the angel Raphael, who banished nine-tenths of the unclean spirits from the earth, leaving but one-tenth for Mastema, to punish sinners through them. Raphael, supported by the chief of the unclean spirits, at that time revealed to Noah all the remedies residing in plants, that he might resort to them at need. Noah recorded them in a book, which he transmitted to his son Shem. This is the source to which go back all the medical books whence the wise men of India, Aram, Macedonia, and Egypt draw their knowledge. The sages of India devoted themselves particularly to the study of curative trees and spices; the Arameans were well versed in the knowledge of the properties of grains and seeds, and they translated the old medical books into their language. The wise men of Macedonia were the first to apply medical knowledge practically, while the Egyptians sought to effect cures by means of magic arts and by means of astrology, and they taught the Midrash of the Chaldees, composed by Kangar, the son of Ur, the son of Kesed. Medical skill spread further and further until the time of aesculapius. This Macedonian sage, accompanied by forty learned magicians, journeyed from country to country, until they came to the land beyond India, in the direction of Paradise. They hoped there to find some wood of the tree of life, and thus spread their fame abroad over the whole world. Their hope was frustrated. When they arrived at the spot, they found healing trees and wood of the tree of life, but when they were in the act of stretching forth their hands to gather what they desired, lightning darted out of the ever-turning sword, smote them to the ground, and they were all burnt. With them disappeared all knowledge of medicine, and it did not revive until the time of the first Artaxerxes, under the Macedonian sage Hippocrates, Dioscorides of Baala, Galen of Caphtor, and the Hebrew Asaph.