"Four are among the tiniest on earth, and yet they are the wisest of the wise" (Proverbs 30:24) these relate to the various empires and monarchs. "Ants are a folk without power, and yet they prepare food for themselves in summer" (Proverbs 30:25). This refers to the Empire of Babylon. As it is written "Behold the land of Chaldea. This is the people that has ceased to be. Assyria founded it to station ships" (Isaiah 23:13). "The badger is a folk without strength, and yet it makes its home in the rock" (Proverbs 30:26). This refers to the Persian-Median Empire. And what is the meaning of "and yet it makes its home in the rock?" This refers to Ahasuerus and Cyrus who sought to rebuild the Holy Temple in Jerusalem. "The locusts have no king, and yet they all march forth in formation" (Proverbs 30:27). This refers to Alexander the Macedonian, for he overtook the entire world as locusts fly through the air. "You can catch the lizard in your hand, and yet it is found in royal palaces" (Proverbs 30:28). This refers to Edom (i.e., the Roman Empire), for of all the small creatures, none are despised like it. And so it is written "And I hated Esau" (Malachi 1:3). And what is the meaning of "and yet it is found in royal palaces?" This also refers to Edom (i.e., Roman Empire), for they destroyed the Holy Temple. "You can catch the lizard in your hand" Said Rabbi Jeremiah, this is Edom the wicked nation, for everything established there in Israel is now destroyed and forgotten.
Ahasuerus and the Patriarchs
Midrash Mishlei 30:7
(משלי ל כד): "ארבעה הם קטני ארץ והמה חכמים מחוכמים": (משלי ל כה): "הנמלים עם לא עז" - זה בבל, שנאמר (ישעיהו כג יג): "הן ארץ כשדים זה העם לא היה אשור יסדה". (משלי ל כו): "שפנים עם לא עצום" - זה מדי, "וישימו בסלע ביתם" - זה אחשורוש וכורש, שביקשו לבנות בית המקדש. (משלי ל כז): "מלך אין לארבה" - זה אלכסנדרוס מוקדון, שנטלטל בכל העולם כולו כארבה שהוא פורח באויר. (משלי ל כח): "שממית בידיים תתפש" - זה אדום, שאין בכל השרצים שנואה כמותה, וכן כתיב (מלאכי א ג): "ואת עשו שנאתי". "והיא בהיכלי מלך" - אדום, שהחריב בית המקדש. "שממית בידיים תתפש" - אמר רבי ירמיה: דא היא אדום אומתא רשיעתא, דכל דקיימא תמן משתכחא.